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Article

Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.

Journal of cellular physiology - 1 Jun 2005

Sakurai Atsuko, Nishimoto Michie, Himeno Seiichiro, Imura Nobumasa, Tsujimoto Masafumi, Kunimoto Manabu, Hara Shuntaro

Abstract excerpt

Thioredoxin reductase (TrxR) is a selenoprotein that catalyzes the reduction of the active site disulfide of thioredoxin (Trx), which regulates the redox status of the cells. In the present study, we found that TrxR1, one of the three TrxR isozymes, was induced by cadmium as well as tumor necrosis factor alpha (TNFalpha) in bovine arterial endothelial cells (BAEC), and investigated the mechanism of...

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PMID: 15521073
DOI: 10.1002/jcp.20246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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