Article
Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis.
Immunology letters - 15 Mar 2006
Roy Eleanor, De Silva A Dharshan, Sambandamurthy Vasan K, Clark Simon O, Stavropoulos Evangelos, Jacobs William R, Brennan John, Chan John, Williams Ann, Colston M Joseph, Tascon Ricardo E
Abstract excerpt
Adoptively transferred dendritic cells presenting antigens derived from different pathogens have been shown to elicit specific T cell responses and to induce protective antibacterial immunity. We describe here the induction of high levels of protective immunity in mice using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis. We provide evidence that protection is superior to BCG and...
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