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Article

Persistence and Protective Efficacy of a Mycobacterium tuberculosis Auxotroph Vaccine

1 Jun 1999

Abstract excerpt

New vaccines against tuberculosis are urgently required because of the impressive incidence of this disease worldwide and the highly variable protective efficacy of the current vaccine. The possibility of creating new live vaccines by the rational attenuation of strains from the Mycobacterium tuberculosis complex was investigated. Two auxotrophic mutants of M. tuberculosis and M. bovis BCG were constructed by...

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Identifiers

PMID: 10338493
DOI: 10.1128/iai.67.6.2867-2873.1999

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