Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates.

Infection and immunity - 1 Feb 2001

Smith D A, Parish T, Stoker N G, Bancroft G J

Abstract excerpt

Auxotrophic mutants of Mycobacterium tuberculosis have been proposed as new vaccine candidates. We have analyzed the virulence and vaccine potential of M. tuberculosis strains containing defined mutations in genes involved in methionine (metB), proline (proC), or tryptophan (trpD) amino acid biosynthesis. The metB mutant was a prototrophic strain, whereas the proC and trpD mutants were auxotrophic for proline and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BCG Vaccine
Share to Mice, Inbred BALB C
Share to Mice, Inbred DBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Mycobacterium tuberculosis

Share to Proline

Share to Tryptophan

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 11160012
DOI: 10.1128/IAI.69.2.1442-1150.2001
PMCID: PMC97996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates.PMID 11160012Read ↗

Comprehensive Characterization of the Attenuated Double Auxotroph Mycobacterium tuberculosisΔleuDΔpanCD as an Alternative to H37RvSemantic proximity Read ↗

Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.Semantic proximity Read ↗

Persistence and Protective Efficacy of a Mycobacterium tuberculosis Auxotroph VaccineSemantic proximity Read ↗

Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.Semantic proximity Read ↗

Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidateSemantic proximity Read ↗

<i>Mycobacterium tuberculosis</i> requires conditionally essential metabolic pathways for infectionSemantic proximity Read ↗

Construction and phenotypic characterization of an auxotrophic mutant of Mycobacterium tuberculosis defective in L-arginine biosynthesis.Semantic proximity Read ↗

Selective requirement of the shikimate pathway of Legionella pneumophila for intravacuolar growth within human macrophages but not within Acanthamoeba.Semantic proximity Read ↗

A parallel intraphagosomal survival strategy shared by mycobacterium tuberculosis and Salmonella enterica.Semantic proximity Read ↗

Role of PPE18 Protein in Intracellular Survival and Pathogenicity of Mycobacterium tuberculosis in MiceSemantic proximity Read ↗

The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacySemantic proximity Read ↗

Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of<i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.