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Article

A temperature sensitive Mycobacterium paragordonae induces enhanced protective immune responses against mycobacterial infections in the mouse model.

Scientific reports - 9 Nov 2017

Kim Byoung-Jun, Kim Bo-Ram, Kook Yoon-Hoh, Kim Bum-Joon

Abstract excerpt

Recently, we introduced a temperature sensitive Mycobacterium spp., Mycobacterium paragordonae (Mpg). Here, we checked its potential as a candidate for live vaccination against Mycobacterium tuberculosis and Mycobacterium abscessus. Intravenous infections of mice with Mpg led to lower colony forming units (CFUs) compared to infection with BCG, suggesting its usefulness as a live vaccine. The analyses of immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29123166
DOI: 10.1038/s41598-017-15458-7
PMCID: PMC5680210

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