Genetic mapping of the cold-adapted phenotype of B/Ann Arbor/1/66, the master donor virus for live attenuated influenza vaccines (FluMist).

doi:10.1016/j.virol.2005.10.005

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Article

Genetic mapping of the cold-adapted phenotype of B/Ann Arbor/1/66, the master donor virus for live attenuated influenza vaccines (FluMist).

Virology - 20 Feb 2006

Chen Zhongying, Aspelund Amy, Kemble George, Jin Hong

Abstract excerpt

Cold adapted (ca) B/Ann Arbor/1/66 is the master donor virus for the influenza B (MDV-B) vaccine component of the live attenuated influenza vaccine (FluMist). The six internal genes contributed by MDV-B confer the characteristic cold-adapted (ca), temperature-sensitive (ts) and attenuated (att) phenotypes to the vaccine strains. Previously, it has been determined that the PA and NP segments of MDV-B control the...

Topics

Adaptation, Physiological
Amino Acid Sequence
Amino Acid Substitution
Animals
Cell Line
Chick Embryo
Cold Temperature
Humans
Influenza B virus
Influenza Vaccines
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleocapsid Proteins

Phenotype

RNA-Dependent RNA Polymerase

Recombination, Genetic

Temperature

Vaccines, Attenuated

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 16289204
DOI: 10.1016/j.virol.2005.10.005

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