Article
Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66.
Journal of virology - 1 Sept 2005
Hoffmann Erich, Mahmood Kutubuddin, Chen Zhongying, Yang Chin-Fen, Spaete Joshua, Greenberg Harry B, Herlocher M Louise, Jin Hong, Kemble George
Abstract excerpt
Cold-adapted (ca) B/Ann Arbor/1/66 is the influenza B virus strain master donor virus for FluMist, a live, attenuated, influenza virus vaccine licensed in 2003 in the United States. Each FluMist vaccine strain contains six gene segments of the master donor virus; these master donor gene segments control the vaccine's replication and attenuation. These gene segments also express characteristic biological traits in...
Topics
- Adaptation, Physiological
- Amino Acids
- Animals
- Cells, Cultured
- Genes, Viral
- Influenza B virus
- Influenza Vaccines
- Nucleocapsid Proteins
- Phenotype
- Phosphoproteins
- Plasmids
- RNA-Dependent RNA Polymerase
- Recombination, Genetic