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Article

Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66.

Journal of virology - 1 Sept 2005

Hoffmann Erich, Mahmood Kutubuddin, Chen Zhongying, Yang Chin-Fen, Spaete Joshua, Greenberg Harry B, Herlocher M Louise, Jin Hong, Kemble George

Abstract excerpt

Cold-adapted (ca) B/Ann Arbor/1/66 is the influenza B virus strain master donor virus for FluMist, a live, attenuated, influenza virus vaccine licensed in 2003 in the United States. Each FluMist vaccine strain contains six gene segments of the master donor virus; these master donor gene segments control the vaccine's replication and attenuation. These gene segments also express characteristic biological traits in...

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Identifiers

PMID: 16103152
DOI: 10.1128/JVI.79.17.11014-11021.2005
PMCID: PMC1193632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66.PMID 16103152Read ↗

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