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Article

Position effect variegations and brain-specific silencing in transgenic mice overexpressing human acetylcholinesterase variants.

Journal of physiology, Paris - 1 Jan 2000

Sternfeld M, Patrick J D, Soreq H

Abstract excerpt

Position effect variegations as well as brain-specific silencing were observed in novel transgenic mouse pedigrees expressing human acetylcholinesterase (AChE) variants. Muscle AChE activities varied between 1.6- and 350-fold of control in these lines, one carrying insertion-inactivated InE6-AChE and two with 'readthrough' I4/E5 AChE, all under control of the ubiquitous CMV promoter. In contrast, brain AChE...

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Identifiers

PMID: 9789818
DOI: 10.1016/s0928-4257(98)80028-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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