Position effect variegations and brain-specific silencing in transgenic mice overexpressing human acetylcholinesterase variants.

doi:10.1016/s0928-4257(98)80028-4

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Article

Position effect variegations and brain-specific silencing in transgenic mice overexpressing human acetylcholinesterase variants.

Journal of physiology, Paris - 1 Jan 2000

Sternfeld M, Patrick J D, Soreq H

Abstract excerpt

Position effect variegations as well as brain-specific silencing were observed in novel transgenic mouse pedigrees expressing human acetylcholinesterase (AChE) variants. Muscle AChE activities varied between 1.6- and 350-fold of control in these lines, one carrying insertion-inactivated InE6-AChE...

Topics

Acetylcholinesterase
Animals
Brain
Gene Expression Regulation, Enzymologic
Genetic Variation
Genome
Humans
Mice
Mice, Transgenic
Muscles
Neuronal Plasticity
Organ Specificity
Pedigree
Stress, Psychological
Xenopus

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