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Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

30 Oct 2020

Abstract excerpt

BACKGROUND: The placenta is the functional interface between the mother and the fetus during pregnancy, and a critical determinant of fetal growth and life-long health. In the first trimester, it develops under a low-oxygen environment, which is essential for the conceptus who has little defense against reactive oxygen species produced during oxidative metabolism. However, failure of invasive trophoblasts to...

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PMID: 33377492
DOI: 10.1093/humupd/dmaa053

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