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Article

Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta

30 Jun 2005

Abstract excerpt

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor composed of HIFalpha and the arylhydrocarbon receptor nuclear translocator (ARNT/HIF1beta). Previously, we have reported that ARNT function is required for murine placental development. Here, we used cultured trophoblast stem (TS) cells to investigate the molecular basis of this requirement. In vitro, wild-type TS cell differentiation is...

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PMID: 15987772
DOI: 10.1242/dev.01923

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