Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia

17 Apr 2019

Abstract excerpt

Human placenta development and a successful pregnancy is incumbent upon precise oxygen-dependent control of trophoblast migration/invasion. Persistent low oxygen leading to failed trophoblast invasion promotes inadequate spiral artery remodeling, a characteristic of preeclampsia. Angiomotin (AMOT) is a multifaceted scaffolding protein involved in cell polarity and migration, yet its upstream regulation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Pregnancy and preeclampsia studies
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30996134
DOI: 10.1172/jci.insight.127009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsiaPMID 30996134Read ↗

Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interfaceSemantic proximity Read ↗

PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migrationSemantic proximity Read ↗

Evaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancySemantic proximity Read ↗

Spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancySemantic proximity Read ↗

Temporal placental genome wide expression profiles reflect three phases of utero-placental blood flow during early to mid human gestationSemantic proximity Read ↗

Spatiotemporal coordination at the maternal-fetal interface promotes trophoblast invasion and vascular remodeling in the first half of human pregnancySemantic proximity Read ↗

Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disordersSemantic proximity Read ↗

Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: The role of decorinSemantic proximity Read ↗

Spatial multiomics map of trophoblast development in early pregnancySemantic proximity Read ↗

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.Semantic proximity Read ↗

Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsiaSemantic proximity Read ↗

Preeclampsia: The Role of Angiogenic Factors in Its PathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.