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Article

The constitutive centromere component CENP-50 is required for recovery from spindle damage.

Molecular and cellular biology - 1 Dec 2005

Minoshima Yukinori, Hori Tetsuya, Okada Masahiro, Kimura Hiroshi, Haraguchi Tokuko, Hiraoka Yasushi, Bao Ying-Chun, Kawashima Toshiyuki, Kitamura Toshio, Fukagawa Tatsuo

Abstract excerpt

We identified CENP-50 as a novel kinetochore component. We found that CENP-50 is a constitutive component of the centromere that colocalizes with CENP-A and CENP-H throughout the cell cycle in vertebrate cells. To determine the precise role of CENP-50, we examined its role in centromere function by generating a loss-of-function mutant in the chicken DT40 cell line. The CENP-50 knockout was not lethal; however,...

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Identifiers

PMID: 16287847
DOI: 10.1128/MCB.25.23.10315-10328.2005
PMCID: PMC1291240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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