Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor necrosis factor (TNF)-functionalized nanostructured particles for the stimulation of membrane TNF-specific cell responses.

Bioconjugate chemistry - 1 Jan 2000

Bryde Susanne, Grunwald Ingo, Hammer Angela, Krippner-Heidenreich Anja, Schiestel Thomas, Brunner Herwig, Tovar Günter E M, Pfizenmaier Klaus, Scheurich Peter

Abstract excerpt

Most members of the tumor necrosis factor (TNF) ligand family occur in both a membrane-bound and a soluble form, which can possess differential bioactivities. The aim of this work was the construction of a synthetic-biological hybrid system consisting of chemically nanostructured core-shell particles with a diameter of 100 nm, 1 microm, or 10 microm and the cytokine TNF to obtain a tool that mimics the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Design
Share to Maleimides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Mimicry

Share to Nanostructures

Share to Particle Size

Share to Receptors, Tumor Necrosis Factor, Type II

Share to Silicon Dioxide

Share to Solubility

Source

Identifiers

PMID: 16287242
DOI: 10.1021/bc0501810

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor (TNF)-functionalized nanostructured particles for the stimulation of membrane TNF-specific cell responses.PMID 16287242Read ↗

A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification.Semantic proximity Read ↗

An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease.Semantic proximity Read ↗

Development and Characterization of a Potent Tumor Necrosis Factor-Alpha Blocking AgentSemantic proximity Read ↗

TNF-related ligands and their receptors.Semantic proximity Read ↗

Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists.Semantic proximity Read ↗

Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology.Semantic proximity Read ↗

Novel protein engineering strategy for creating highly receptor-selective mutant TNFs.Semantic proximity Read ↗

A mutated human tumor necrosis factor-alpha improves the therapeutic index in vitro and in vivo.Semantic proximity Read ↗

A New Venue of TNF TargetingSemantic proximity Read ↗

Production and characterization of receptor-specific TNF muteins.Semantic proximity Read ↗

Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window.Semantic proximity Read ↗

Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.