Article
Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2016
Efimov Grigory A, Kruglov Andrei A, Khlopchatnikova Zoya V, Rozov Fedor N, Mokhonov Vladislav V, Rose-John Stefan, Scheller Jürgen, Gordon Siamon, Stacey Martin, Drutskaya Marina S, Tillib Sergei V, Nedospasov Sergei A
Abstract excerpt
Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti-TNF therapy. TNF is produced by a variety of cell types, and it can play either a beneficial or a deleterious role. In particular, in autoimmunity pathogenic TNF may be derived from restricted cellular sources. In this study we evaluated the feasibility of cell-type-restricted TNF...
Topics
- Amino Acid Substitution
- Animals
- Antibodies, Bispecific
- Antibodies, Neutralizing
- Antibody Specificity
- Antigen-Antibody Reactions
- Antigens, Differentiation
- Antigens, Surface
- Camelus