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Article

Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists.

Journal of biochemistry - 1 Aug 2009

Mukai Yohei, Nakamura Teruya, Yoshioka Yasuo, Shibata Hiroko, Abe Yasuhiro, Nomura Tetsuya, Taniai Madoka, Ohta Tsunetaka, Nakagawa Shinsaku, Tsunoda Shin-ichi, Kamada Haruhiko, Yamagata Yuriko, Tsutsumi Yasuo

Abstract excerpt

Tumour necrosis factor (TNF) is an important cytokine that induces an inflammatory response predominantly through the TNF receptor-1 (TNFR1). A crucial strategy for the treatment of many autoimmune diseases, therefore, is to block the binding of TNF to TNFR1. We previously identified a TNFR1-selective antagonistic mutant TNF (R1antTNF) from a phage library containing six randomized amino acid residues at the...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19386778
DOI: 10.1093/jb/mvp065

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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