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Small Molecule Drugs Targeting Viral Polymerases

20 May 2024

Abstract excerpt

Small molecules that specifically target viral polymerases-crucial enzymes governing viral genome transcription and replication-play a pivotal role in combating viral infections. Presently, approved polymerase inhibitors cover nine human viruses, spanning both DNA and RNA viruses. This review provides a comprehensive analysis of these licensed drugs, encompassing nucleoside/nucleotide inhibitors (NIs),...

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PMID: 38794231
DOI: 10.3390/ph17050661

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