Article
Prion genotypes in Central America suggest selection for the V129 allele.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2006
Hardy John, Scholz Sonja, Evans Whitney, Goldfarb Lev, Singleton Andrew
Abstract excerpt
Using the well-characterized, human diversity sample series, we show that the V129 prion allele has a very high frequency in South American populations relative to the East Asian populations from which it arose. We suggest there has been selection at the prion locus, possibly mediated by Kuru-like diseases, which has influenced its allele frequency.
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