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Article

Is the prevalent human prion protein 129M/V mutation a living fossil from a Paleolithic panzootic superprion pandemic?

Prion - 1 Jan 2000

Nyström Sofie, Hammarström Per

Abstract excerpt

Prion diseases are consistently associated with prion protein (PrP(C)) misfolding rendering a cascade of auto-catalytic self-perpetuation of misfolded PrP in an afflicted individual. The molecular process is intriguingly similar to all known amyloid diseases both local and systemic. The prion disease is also infectious by the transfer of misfolded PrP from one individual to the next. Transmissibility is...

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Identifiers

PMID: 24398570
DOI: 10.4161/pri.27601
PMCID: PMC7030913

Genes

PRNP

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