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Article

Differing evolutionary histories of the ACTN3*R577X polymorphism among the major human geographic groups.

PloS one - 1 Jan 2015

Amorim Carlos Eduardo G, Acuña-Alonzo Victor, Salzano Francisco M, Bortolini Maria Cátira, Hünemeier Tábita

Abstract excerpt

It has been proposed that the functional ACTN3*R577X polymorphism might have evolved due to selection in Eurasian human populations. To test this possibility we surveyed all available population-based data for this polymorphism and performed a comprehensive evolutionary analysis of its genetic diversity, in order to assess the action of adaptive and random mechanisms on its variation across human geographical...

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Identifiers

PMID: 25706920
DOI: 10.1371/journal.pone.0115449
PMCID: PMC4338210

Genes

ACTN3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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