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Article

A pre-Columbian Y chromosome-specific transition and its implications for human evolutionary history.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 1996

Underhill P A, Jin L, Zemans R, Oefner P J, Cavalli-Sforza L L

Abstract excerpt

A polymorphic C-->T transition located on the human Y chromosome was found by the systematic comparative sequencing of Y-specific sequence-tagged sites by denaturing high-performance liquid chromatography. The results of genotyping representative global indigenous populations indicate that the locus is polymorphic exclusively within the Western Hemisphere. The pre-Columbian T allele occurs at > 90% frequency...

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Identifiers

PMID: 8552603
DOI: 10.1073/pnas.93.1.196
PMCID: PMC40205

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