Article
Variation of the prion gene in chimpanzees and its implication for prion diseases.
Neuroscience letters - 30 Jan 2004
Soldevila M, Andrés A M, Blancher A, Calafell F, Ordoñez M, Pumarola M, Oliva B, Aramburu J, Bertranpetit J
Abstract excerpt
In humans, familial prion diseases are linked to mutations in the PRNP gene. We have sequenced part of this gene in a large sample of common chimpanzee, Pan troglodytes (n=130 chromosomes). No variation in codons 129 and 219 has been observed: all chimpanzees were homozygous for the Met allele, which in humans increases susceptibility to Creutzfeldt-Jakob disease. We found two sequence variants: one is a...
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