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Article

The prion protein gene in humans revisited: lessons from a worldwide resequencing study.

Genome research - 1 Feb 2006

Soldevila Marta, Andrés Aida M, Ramírez-Soriano Anna, Marquès-Bonet Tomàs, Calafell Francesc, Navarro Arcadi, Bertranpetit Jaume

Abstract excerpt

Ample evidence has accumulated showing that different coding variants of the PRNP gene confer differential susceptibility for prion diseases. Here we evaluate the patterns of nucleotide variation in PRNP exon 2, which includes all the protein-coding sequence, by resequencing a worldwide sample of 174 humans for 2378 bp. In line with previous studies, we found two main haplotypes differentiated by nonsynonymous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16369046
DOI: 10.1101/gr.4345506
PMCID: PMC1361719

Genes

PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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