Article
SAGA and Rpd3 chromatin modification complexes dynamically regulate heat shock gene structure and expression.
The Journal of biological chemistry - 20 Nov 2009
Kremer Selena B, Gross David S
Abstract excerpt
The chromatin structure of heat shock protein (HSP)-encoding genes undergoes dramatic alterations upon transcriptional induction, including, in extreme cases, domain-wide nucleosome disassembly. Here, we use a combination of gene knock-out, in situ mutagenesis, chromatin immunoprecipitation, and expression assays to investigate the role of histone modification complexes in regulating heat shock gene structure and...
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