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Article

Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy.

AIDS (London, England) - 2 Dec 2005

Verstuyft Céline, Marcellin Fabienne, Morand-Joubert Laurence, Launay Odile, Brendel Karl, Mentré France, Peytavin Gilles, Gérard Laurence, Becquemont Laurent, Aboulker Jean Pierre

Abstract excerpt

OBJECTIVE: The relationship between MDR1 single nucleotide polymorphisms (SNP) and the pharmacokinetic or pharmacodynamic responses to protease inhibitors has been recently challenged. AIM: The objective of the present study was to determine whether MDR1 genetic polymorphisms in exons 21 and 26 (G2677T/A and C3435T) are in association with indinavir (IDV) plasma concentrations and/or therapeutic response to...

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Identifiers

PMID: 16284462
DOI: 10.1097/01.aids.0000196122.91633.04

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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