Pharmacogenetics of toxicity, plasma trough concentration and treatment outcome with nevirapine-containing regimen in anti-retroviral-naïve HIV-infected adults: an exploratory study of the TRIANON ANRS 081 trial.

doi:10.1111/j.1742-7843.2011.00780.x

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Pharmacogenetics of toxicity, plasma trough concentration and treatment outcome with nevirapine-containing regimen in anti-retroviral-naïve HIV-infected adults: an exploratory study of the TRIANON ANRS 081 trial.

Basic & clinical pharmacology & toxicology - 1 Dec 2011

Gozalo Claire, Gérard Laurence, Loiseau Pascale, Morand-Joubert Laurence, Peytavin Gilles, Molina Jean-Michel, Dellamonica Pierre, Becquemont Laurent, Aboulker Jean-Pierre, Launay Odile, Verstuyft Céline

Abstract excerpt

The aim of this exploratory study was to investigate in a homogeneous population of anti-retroviral naïve HIV-1-infected adults, the relationships between genetic polymorphisms involved in nevirapine metabolism [CYP2B6 516G>T, 785A>G and 1459C>T; CYP3A5 6986A>G (CYP3A5*3)], transport (ABCB1 2677G>T/A and 3435C>T), and antigen recognition (HLA-DRB1*0101), and the hepatic and/or cutaneous toxicity occurring within...

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PMID: 21824325
DOI: 10.1111/j.1742-7843.2011.00780.x

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ABCB1

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