Article
MDR1 genotypes do not influence the absorption of a single oral dose of 600 mg valacyclovir in healthy Chinese Han ethnic males.
British journal of clinical pharmacology - 1 Aug 2008
Zhang Yan, Jiang Xue-Hua, Hu Yu-Qin, Li Zhi-Ru, Su Lan, Wang Zhan-Guo, Ma Guo
Abstract excerpt
AIMS: To investigate the influence of three single nucleotide polymorphisms (SNPs) in exon 12 (C1236T), exon 21 (G2677T/A) and exon 26 (C3435T) of MDR1 gene on the absorption of valacyclovir after a single oral administration in the Chinese Han ethnic population. METHODS: Two hundred healthy Chinese subjects were genotyped for the SNPs of C1236T, G2677T/A and C3435T in the MDR1 gene using allele-specific...
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