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Article

MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients

1 Jul 2003

Abstract excerpt

P-glycoprotein, a membrane-localized protein transporter, codified by theMDR1gene, influences the response to pharmacological treatments, including antiretroviral drugs.MDR1polymorphism C3435T is correlated with the functionality of the protein. We investigated the influence of this polymorphism in the reconstitution of the peripheral CD4 T cell pool in 149 drug-naive HIV-positive patients starting highly active...

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PMID: 12853754
DOI: 10.1097/00002030-200307250-00016

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