Article
The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation.
Cancer research - 1 Dec 2003
Bhattacharya Anuradha, Deng Jian Min, Zhang Zhaoping, Behringer Richard, de Crombrugghe Benoit, Maity Sankar N
Abstract excerpt
To understand the physiological function of the mammalian heterotrimeric CCAAT binding factor CBF, also known as NF-Y, we have generated a conditional Cbf-b mouse mutant by introducing loxP sites in the murine Cbf-b/Nf-ya gene. Controlled expression of Cre recombinase deletes the gene in vivo, which leads to a loss of DNA binding by the CBF complex and hence CBF-mediated transcription. Deletion of both Cbf-b...
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