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Article

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation

11 Nov 2005

Abstract excerpt

A major determinant in platelet production is the megakaryocyte (MK) size that is regulated both by ploidization and the increase in cytoplasmic volume at the end of maturation. Here we investigated the involvement of the mammalian target of rapamycin (mTOR) pathway in the regulation of megakaryopoiesis. We show that phosphorylation of mTOR, p70S6K1, and 4E-BP1 was diminished in thrombopoietin-cultured human MKs...

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Share to PI3K/AKT/mTOR signaling in cancer
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PMID: 16282343
DOI: 10.1182/blood-2005-07-3005

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Related research

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Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiationPMID 16282343Read ↗

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.Semantic proximity Read ↗

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