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Article

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.

The Journal of biological chemistry - 13 Jan 2006

Qi Xiao-Jun, Wildey Gary M, Howe Philip H

Abstract excerpt

Bim, the Bcl-2 interacting mediator of cell death, is a member of the BH3-only family of pro-apoptotic proteins. Recent studies have demonstrated that the apoptotic activity of Bim can be regulated through a post-translational mechanism whereby ERK phosphorylation serves as a signal for Bim ubiquitination and proteasomal degradation. In this report, we investigated the signaling pathways leading to Bim...

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PMID: 16282323
DOI: 10.1074/jbc.M505546200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.PMID 16282323Read ↗

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