Article
The G protein-coupled receptors: pharmacogenetics and disease.
Critical reviews in clinical laboratory sciences - 1 Jan 2005
Thompson Miles D, Burnham W McIntyre, Cole David E C
Abstract excerpt
Genetic variation in G-protein coupled receptors (GPCRs) is associated with a wide spectrum of disease phenotypes and predispositions that are of special significance because they are the targets of therapeutic agents. Each variant provides an opportunity to understand receptor function that complements a plethora of available in vitro data elucidating the pharmacology of the GPCRs. For example, discrete portions...
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