Article
G protein-coupled receptor pharmacogenetics.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
Thompson Miles D, Siminovitch Katherine A, Cole David E C
Abstract excerpt
Common G protein-coupled receptor (GPCR) gene variants that encode receptor proteins with a distinct sequence may alter drug efficacy without always resulting in a disease phenotype. GPCR genetic loci harbor numerous variants, such as DNA insertions or deletions and single-nucleotide polymorphisms that alter GPCR expression and function, thereby contributing to interindividual differences in disease...
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