Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.

Abstract excerpt

G protein coupled receptors (GPCRs) are a large superfamily of integral cell surface plasma membrane proteins that play key roles in transducing extracellular signals, including sensory stimuli, hormones, neurotransmitters, or paracrine factors into the intracellular environment through the activation of one or more heterotrimeric G proteins. Structural alterations provoked by mutations or variations in the genes...

Topics

• Animals
• Humans
• Hypogonadism
• Mutation
• Protein Transport
• Receptors, G-Protein-Coupled
• Reproduction