An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.

doi:10.1091/mbc.e05-06-0523

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Article

An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.

Molecular biology of the cell - 1 Jan 2006

Jovanovic Olivera A, Brown Fraser D, Donaldson Julie G

Abstract excerpt

In this study, we investigated the role of phospholipase D (PLD) in mediating Arf6 function in cells. Expression of Arf6 mutants that are defective in activating PLD, Arf6N48R and Arf6N48I, inhibited membrane recycling to the plasma membrane (PM), resulting in an accumulation of tubular endosomal membranes. Additionally, unlike wild-type Arf6, neither Arf6 mutant could generate protrusions or recruit the Arf6...

Topics

ADP-Ribosylation Factor 6
ADP-Ribosylation Factors
Aluminum Compounds
Asparagine
Endosomes
Enzyme Activation
Fluorides
GTPase-Activating Proteins
HeLa Cells
Humans
Intracellular Membranes
Mutation
Phenotype
Phospholipase D

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Identifiers

PMID: 16280360
DOI: 10.1091/mbc.e05-06-0523
PMCID: PMC1345670

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