Article
The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.
The Journal of biological chemistry - 3 Jun 2005
Paleotti Olivia, Macia Eric, Luton Frederic, Klein Stephanie, Partisani Mariagrazia, Chardin Pierre, Kirchhausen Tom, Franco Michel
Abstract excerpt
The small GTP-binding protein ADP-ribosylation factor 6 (Arf6) is involved in plasma membrane/endosomes trafficking. However, precisely how the activation of Arf6 regulates vesicular transport is still unclear. Here, we show that, in vitro, recombinant Arf6GTP recruits purified clathrin-adaptor complex AP-2 (but not AP-1) onto phospholipid liposomes in the absence of phosphoinositides. We also show that...
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