Article
Detection of the (--SEA) double alpha-globin gene deletion by a simple immunologic assay for embryonic zeta-globin chains.
American journal of hematology - 1 Sept 1993
Ireland J H, Luo H Y, Chui D H, Chu B, Yuen J, Hsia Y E
Abstract excerpt
Homozygous alpha-thalassemia [alpha-thal-1], with loss of all four alpha-globin genes, causes lethal hydrops fetalis. The most common mutation producing this syndrome is the Southeast Asian (--SEA) double alpha-globin gene deletion. Erythrocytes from adults heterozygous for the (--SEA) deletion h...
Topics
- Antibodies, Monoclonal
- Asia, Southeastern
- Asian People
- Chromatography, High Pressure Liquid
- DNA
- DNA Probes
- Fetal Proteins
- Gene Deletion
- Genes
- Globins
- Heterozygote
- Humans
- Mass Screening
- Mutation
- Thalassemia