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Article

A functional element necessary for fetal hemoglobin silencing.

The New England journal of medicine - 1 Sept 2011

Sankaran Vijay G, Xu Jian, Byron Rachel, Greisman Harvey A, Fisher Chris, Weatherall David J, Sabath Daniel E, Groudine Mark, Orkin Stuart H, Premawardhena Anuja, Bender M A

Abstract excerpt

BACKGROUND: An improved understanding of the regulation of the fetal hemoglobin genes holds promise for the development of targeted therapeutic approaches for fetal hemoglobin induction in the β-hemoglobinopathies. Although recent studies have uncovered trans-acting factors necessary for this regulation, limited insight has been gained into the cis-regulatory elements involved. METHODS: We identified three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21879898
DOI: 10.1056/NEJMoa1103070
PMCID: PMC3174767

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