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Article

Epigenetic regulation of fetal globin gene expression in adult erythroid cells

11 May 2014

Abstract excerpt

The developmental regulation of globin gene expression has served as an important model for understanding higher eukaryotic transcriptional control mechanisms. During human erythroid development, there is a sequential switch from expression of the embryonic ε-globin gene to the fetal ɣ-globin gene in utero, and postpartum the ɣ-globin gene is silenced, as the β-globin gene becomes the predominantly expressed...

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PMID: 24880147
DOI: 10.1016/j.trsl.2014.05.002

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