Article
Immunocytological test to detect adult carriers of (--SEA/) deletional alpha-thalassaemia.
Lancet (London, England) - 6 Nov 1993
Tang W, Luo H Y, Eng B, Waye J S, Chui D H
Abstract excerpt
The gene frequency for (--SEA/) deletional alpha-thalassaemia is high in Southeast Asian populations. We report a simple immunocytological test that is highly sensitive and specific for the detection of adult carriers of the (--SEA/) deletion. We prospectively studied 206 consecutive adult blood samples. All 41 with the (--SEA/) deletion had a positive test; all but 1 of the 165 non-carriers were negative. This...
Topics
- Adult
- Asia, Southeastern
- Gene Frequency
- Genetic Carrier Screening
- Genotype
- Humans
- Polymerase Chain Reaction
- Prospective Studies
- alpha-Thalassemia