Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of UGT1A6 isoform by inflammatory conditions in rat astrocytes.

Neuropharmacology - 1 Mar 2006

Heurtaux T, Benani A, Moulin D, Muller N, Netter P, Minn A

Abstract excerpt

Alteration of drug metabolism under diseased conditions is of clinical importance. We have investigated the effects of inflammatory conditions on phase II drug-metabolizing enzyme activity in rat cultured astrocytes. Lipopolysaccharide (LPS) treatment was used to promote inflammatory conditions. Thus, we reported that LPS initiates an inflammatory response, which is mediated by pro-inflammatory mediators and free...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Dinoprostone
Share to Drug Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Induction

Share to Glucuronosyltransferase

Share to Interleukin-1

Share to Nitrites

Share to Rats, Wistar

Source

Identifiers

PMID: 16274708
DOI: 10.1016/j.neuropharm.2005.09.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Induction of UGT1A6 isoform by inflammatory conditions in rat astrocytes.PMID 16274708Read ↗

CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunctionSemantic proximity Read ↗

Inhibition of 20-hydroxyeicosatetraenoic acid (20-HETE) glucuronidation by non-steroidal anti-inflammatory drugs in human liver microsomes and recombinant UDP-glucuronosyltransferase enzymes.Semantic proximity Read ↗

Variability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism.Semantic proximity Read ↗

Regulation of cytochrome P450 enzyme activity and expression by nitric oxide in the context of inflammatory diseaseSemantic proximity Read ↗

Genotype-dependent down-regulation of gene expression and function of MDR1 in human peripheral blood mononuclear cells under acute inflammation.Semantic proximity Read ↗

Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes.Semantic proximity Read ↗

Regulation of Cytochromes P450 During Inflammation and InfectionSemantic proximity Read ↗

Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation.Semantic proximity Read ↗

The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility in astrocytes.Semantic proximity Read ↗

Stimulation of transcriptional expression of human UDP-glucuronosyltransferase 1A1 by dexamethasone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.