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Article

Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes.

Metabolic brain disease - 1 Sept 2009

Borysiewicz Elizabeth, Fil Daniel, Dlaboga Daniel, O'Donnell James M, Konat Gregory W

Abstract excerpt

Cyclic AMP is part of an endogenous mechanism that downregulates inflammatory response, and its intracellular concentration is regulated chiefly by cyclic nucleotide phosphodiesterases type 4. The goal of the present study was to determine whether phosphodiesterases 4 are involved in the inflammatory response of astrocytes mediated by Toll-like receptors. Astrocyte cultures established from newborn rat brain were...

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PMID: 19728060
DOI: 10.1007/s11011-009-9150-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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