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The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

4 Mar 2016

Abstract excerpt

As a first-line vertebrate immune defense, the polymeric immunoglobulin receptor (pIgR) transports polymeric IgA and IgM across epithelia to mucosal secretions, where the cleaved ectodomain (secretory component; SC) becomes a component of secretory antibodies, or when unliganded, binds and excludes bacteria. Here we report the 2.6Å crystal structure of unliganded human SC (hSC) and comparisons with a 1.7Å...

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PMID: 26943617
DOI: 10.7554/elife.10640

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