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Article

Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly

1 Jul 1996

Abstract excerpt

The structural features of the human IgA1 tailpiece required for interaction with J chain in IgA dimer assembly were investigated using a protein engineering approach. Wild-type and mutant forms of IgA1 were expressed in the mouse myeloma cell line, J558L, which endogenously expresses J chain. Wild-type IgA1 was secreted as a mixture of dimers and monomers. Deletion of the entire tailpiece by stop codon...

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Identifiers

PMID: 8683109
DOI: 10.4049/jimmunol.157.1.156

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Source receipt: pubmed, retrieved 7 Sept 2026.

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