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Article

Role of J chain in secretory immunoglobulin formation.

Scandinavian journal of immunology - 1 Sept 2000

Johansen F E, Braathen R, Brandtzaeg P

Abstract excerpt

The joining (J) chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. First, a high valency of antigen-binding sites, which makes them suitable for agglutinating bacteria and viruses;...

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Identifiers

PMID: 10972899
DOI: 10.1046/j.1365-3083.2000.00790.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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