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JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis

16 Jun 2008

Abstract excerpt

JNK1/2 proteins belong to the family of stress-activated protein kinases. They play a complex role in growth regulation, inducing either cell death or growth support. In this report, we provide evidence that, in human melanoma cells, JNK inhibition with the small molecule inhibitor SP600125 induces either predominantly a G2/M arrest or apoptosis depending on the cell line. In 1205Lu cells, JNK inhibition induced...

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PMID: 18541008
DOI: 10.1111/j.1755-148x.2008.00466.x

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