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Article

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

Cancer research - 15 Feb 1993

Reiss M, Vellucci V F, Zhou Z L

Abstract excerpt

Human carcinoma cell lines are frequently refractory to the antiproliferative effect of the autocrine growth inhibitor transforming growth factor beta 1 (TGF-beta 1) and often express mutant forms of the tumor suppressor gene p53. Therefore, we wished to determine whether mutant p53 affects the cellular response to TGF-beta 1. A murine p53 complementary DNA carrying an activating point mutation was introduced...

Topics

Animals
Cell Division
Cell Line, Transformed
Drug Resistance
Gene Expression Regulation, Neoplastic
Genes, p53
Keratinocytes
Mice
Mutation
Phenotype
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, ErbB-2

Transfection

Transforming Growth Factor beta

Source

Identifiers

PMID: 8094035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8094035-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.PMID 8094035Read ↗

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