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Article

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

Cancer research - 15 Feb 1993

Reiss M, Vellucci V F, Zhou Z L

Abstract excerpt

Human carcinoma cell lines are frequently refractory to the antiproliferative effect of the autocrine growth inhibitor transforming growth factor beta 1 (TGF-beta 1) and often express mutant forms of the tumor suppressor gene p53. Therefore, we wished to determine whether mutant p53 affects the cellular response to TGF-beta 1. A murine p53 complementary DNA carrying an activating point mutation was introduced...

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PMID: 8094035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.PMID 8094035Read ↗

Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.Semantic proximity Read ↗

Mutant p53 Attenuates the SMAD-Dependent Transforming Growth Factor β1 (TGF-β1) Signaling Pathway by Repressing the Expression of TGF-β Receptor Type IISemantic proximity Read ↗

Anchorage-independent growth of p53-knockout dermal fibroblasts is reversed by wild-type p53.Semantic proximity Read ↗

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA.Semantic proximity Read ↗

p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene.Semantic proximity Read ↗

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.Semantic proximity Read ↗

Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein.Semantic proximity Read ↗

The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation.Semantic proximity Read ↗

Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein.Semantic proximity Read ↗

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Aberrant expression of p53 tumour-suppressor protein in non-melanoma skin cancer.Semantic proximity Read ↗

Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles.Semantic proximity Read ↗

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