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Article

High prevalence of mutations in perilipin 1 in patients with precocious acute coronary syndrome.

Atherosclerosis - 1 Jan 2020

Bonello-Palot Nathalie, Laine Marc, Cuisset Thomas, Ronchard Thibault, Desgrouas Camille, Merono Françoise, Ibrahim-Kosta Manal, Cerino Mathieu, Blanchard Arnaud, Bourgeois Patrice, Levy Nicolas, Loundou Anderson, Morange Pierre-Emmanuel, Alessi Marie-Christine, Badens Catherine, Bonello Laurent

Abstract excerpt

BACKGROUND AND AIMS: Genetic partial lipodystrophies are rare heterogeneous disorders characterized by abnormalities of fat distribution and associated metabolic complications including a predisposition for atherosclerotic cardiovascular disease. We hypothesized that the milder forms of these diseases might be underdiagnosed and might result in early acute coronary syndrome (ACS) as the first sign of the...

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PMID: 31877397
DOI: 10.1016/j.atherosclerosis.2019.12.002

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