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Article

KLOTHO allele status and the risk of early-onset occult coronary artery disease.

American journal of human genetics - 1 May 2003

Arking Dan E, Becker Diane M, Yanek Lisa R, Fallin Daniele, Judge Daniel P, Moy Taryn F, Becker Lewis C, Dietz Harry C

Abstract excerpt

We previously identified a functional variant of KLOTHO (termed "KL-VS"), which harbors two amino acid substitutions in complete linkage disequilibrium and is associated with reduced human longevity when in homozygosity. Klotho-deficient mice display extensive arteriosclerosis when fed a normal d...

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Identifiers

PMID: 12669274
DOI: 10.1086/375035
PMCID: PMC1180268

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12669274-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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KLOTHO allele status and the risk of early-onset occult coronary artery disease.PMID 12669274Read ↗

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.Semantic proximity Read ↗

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The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect.Semantic proximity Read ↗

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.Semantic proximity Read ↗

Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis.Semantic proximity Read ↗

Aging syndrome genes and premature coronary artery disease.Semantic proximity Read ↗

Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke.Semantic proximity Read ↗

The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease.Semantic proximity Read ↗

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A monocyte chemoattractant protein-1 gene polymorphism is associated with occult ischemia in a high-risk asymptomatic population.Semantic proximity Read ↗

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Association of human aging with a functional variant of klotho.Semantic proximity Read ↗

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