Article
Single nucleotide polymorphisms within LIPA (Lysosomal Acid Lipase A) gene are associated with susceptibility to premature coronary artery disease. a replication in the genetic of atherosclerotic disease (GEA) Mexican study.
PloS one - 1 Jan 2013
Vargas-Alarcón Gilberto, Posadas-Romero Carlos, Villarreal-Molina Teresa, Alvarez-León Edith, Angeles Javier, Vallejo Maite, Posadas-Sánchez Rosalinda, Cardoso Guillermo, Medina-Urrutia Aida, Kimura-Hayama Eric
Abstract excerpt
AIM: The rs1412444 and rs2246833 polymorphisms within the LIPA gene were recently found to be significantly associated with coronary artery disease (CAD) in genome-wide association studies in Caucasian and Asian populations. The aim of the present study was to replicate this association in an independent population with a different genetic background. METHODS: The rs1412444 and rs2246833 polymorphisms of the LIPA...