Article
The use of neurophysiological endophenotypes to understand the genetic basis of schizophrenia.
Dialogues in clinical neuroscience - 1 Jan 2005
Braff David L, Light Gregory A
Abstract excerpt
Specifying the complex genetic architecture of the "fuzzy" clinical phenotype of schizophrenia is an imposing problem. Utilizing metabolic, neurocognitive, and neurophysiological "intermediate" endophenotypic measures offers significant advantages from a statistical genetics standpoint. Endophenotypic measures are amenable to quantitative genetic analyses, conferring upon them a major methodological advantage...
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